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Case Analysis : Stem Cell Therapy for Cerebral Infarction

by Drs.Like Wu, Xiaojuan Wang and Bo Cheng

No matter the morbidity rate or impotence, cerebrovascular disorder is on the top of all nervous system diseases found in adults. A stroke is brain abnormalities which are caused by the pathological process of the blood vessels. This disease is normally presented in acute attack in the middle-aged people and/or elderly, which may cause consciousness disorder and limb paralysis. Stroke is a major disease that can cause death and physical disability; the main cause of death for patients is when they present high blood pressure results.

According to a different property, the classification of strokes is a ischemic cerebral vascular disease and a hemorrhagic cerebrovascular disease. Ischemic cerebral vascular disease is more common, cerebral infarction occupies 59.2%~85%, cerebral hemorrhage is less than 20% in different countries, except Japan.

Ischemic cerebral vascular disease:
(1) Transient ischemic attack (TIA, small stroke) etiological factor is related to cerebral arteriosclerosis. This is a kind of functional disorder caused by the brain tissue transient, ischemia, and focal lesions.

(2) Cerebral thrombosis is a blood clot formed from the cerebral blood vessel local lesions, which is caused by atherosclerosis, arthritis, trauma, blood disease and other physical factors.

(3) Cerebral embolism may be caused by an embolus, from many kinds of diseases, or an obstruction of the blood vessels in the brain. Although, heart disease is the most common cause, next in importance are embolus from fractures, or post-traumatic fat in the blood, eggs or bacterial infection, pneumothorax air into the blood, and/or phlebophlogosis.

Hemorrhagic cerebrovascular disease
(1) Cerebral hemorrhage is a cerebral vascular rupture with bleeding; this is not including the traumatic cerebral hemorrhage. Cerebral hemorrhages are commonly caused by hypertension, cerebral arteriosclerosis, tumors, etc.
(2) Subarachnoid hemorrhage is caused by a vascular rupture on the surface of the brain and the base of the brain with bleeding; the blood flows straight into the cavum subarachnoidale. Common causes are an aneurysm, vascular malformations, hypertension, arteriosclerosis, blood diseases, etc.

Pathology of Stroke

The pathology of cerebral ischemia and ischemic infarction include two pathological and physiological processes:
1. Shortage of oxygen and glucose caused by secondary vascular occlusion.
2. Tissue capacity processes collapse, a series of endocrine and metabolic changes occur in the cells and the cells membrane decomposition.
Above pathology changes may cause a variety of symptoms, such as: stroke syndrome: abrupt non-convulsive, focal neurological deficits. The most serious type is when patients have hemiplegic paralysis, or even coma.

Neurovascular Syndrome: Different arterial occlusion and patients physical quality is caused by different symptoms, but there are still some typical symptoms: such as three partial syndromes and lacunar syndrome in pars geniculate artery stroke, etc.

Course and Prognosis of Stroke
Generally, when the later rehabilitation training begins the prognosis worsens. If patient begins to have rehabilitation training 2 weeks after stroke, then he will have poor hope of motor and language function recovery. Movement and language disorders will be a permanent disability for them if they last 5-6 months.

Advance in the Treatment of Stroke
Generally it is thought that stroke is preventable by paying attention to blood pressure levels, blood glucose levels, blood lipid levels, diet and body mass index can effectively prevent a stroke from occurring. For patients who have one cerebrovascular occlusion, they should pay attention to cerebral vascular occlusion in different blood vessels, which can occur again. For patients who have had sequel already, it was thought that there was no effective treatment to recover any functions, but they still can have rehabilitation training to keep muscle away from atrophy. With the development of science and technology, new treatments for patients who are suffering from stroke disability is now available, this kind of new treatment belongs to the field of regenerative medicine.

Wu Stem Cells Medical Center found that necrotic nerve cells cannot regenerate after they die, which is caused by extensive damage of ischemia and hypoxia, but reserve cells and the cells around the lesion can be activated and are useable, which is brought about by regulation of the neural stem cell transplantation.

Wu Stem Cells Medical Center researchers found that the cerebrovascular disease is caused by vascular pathological factors resulting in nerve cell necrosis and number decrease, then the cells function is reduced or even lost, supplement neural stem cells can be activated in the expression function of the cells in the tissue, those viable neural stem cells can lead the reserve cells in the tissue to react, migrate and differentiate. They can also start the vascular reconstruction and repair a part of the remnant lesions, so the number of neural cells are increased, promoting function and recovering the function which was lost.

Case analysis

by Drs. Pearly Liu, Xiaojuan Wang and Like Wu

The patient is a 70-year-old male. He has had limitations to the movement in both right side limbs and speech impediments for more than 1 year.

Diagnosis: Cerebral infarction

Patient has had hypertension for more than 10 years, his highest blood pressure reading was 220/120 mmHg. Two years ago, he contracted cerebral infarction, with the accompanying speech impediments. His condition improved after one month's treatment, does not have sequela, diabetes, or coronary disease.

Admission PE: Bp 150/95 mmHg, HR 90/min. His heart, lungs and abdomen are all ok.

Neural system examination:

Alert, mental status weak, incomplete motor aphasia. His memory, cognition and orientation are all ok. The bilateral pupils are equal and round, diameter is about 2.5mm, has good sensitivity response to light, and ocular movement is flexible. The bilateral grain of the forehead and the condition of the teeth and tongue are good. The uvula is slightly averted to the left; the nasolabial groove on the right side is shallow. The right side of the mouth is lower than the left side. Pharyngeal reflex shows inertia. His neck is soft, and his shrugging ability is strong. The muscle force of the right arm is 3 degrees; the muscle force of the right leg is 4 degrees. The muscle force of the right side is higher than normal. Tendon reflex of all four limbs is low. Abdominal reflex on the right side is nonexistent. Bilateral palmomental reflex is positive, negative Hoffmann sign on the right side, positive Babinski sign on the right side. There was some uncoordinated movement when attempting to point to each side, especially concerning the right arm. Inspection of the tibia is incomplete because of the instability of the right leg.

Auxiliary inspection:

MRI (9.4.15) 1.The left side frontal and basal ganglia area has cerebral infarction.

2. Bilateral sub cortical degeneration multiple foci.

Rapid blood sugar inspection (09.5.7): 12.2mmol/l (limosis).

Electrocardiogram (09.5.7): sinus rhythm, left axis deviation, widespread ST-T is low and level.

Blood-fat (09.5.8): TG1.73mmol/l??LDL3.32mmol/l.

Urine routine (09.5.8): urine sugar, others normal.

Diagnoses: 1.multiple cerebral infarction

2. hypertension 3 grade, extremely high-risk

3. type 2 diabetes

4. hyperlipidemia

Treatment protocols:

1. Plan and implement an appropriate diet, limit the total amount of food intake.

2. Give medication to control blood pressure, blood sugar, and blood-fat levels.

3. Improve blood circulation, give treatment to resist arteriosclerosis.

4. The patient is given four stem cells implantation treatments and self stem

cells activation treatments to repair the damage to the neurons. The patient

receives treatment for the purpose of nourishing the neurons, together with

daily rehabilitation training to promote the recovery of motor functioning, and

to improve the overall quality of life.

5. Properly and accurately assess any risk factors and adjust the treatment

plan accordingly.

Treatment results:

The patient's condition has shown good improvement after the five week treatment plant: His diabetic condition has improved, and he is on a low-fat, low-salt diet, blood pressure is under control, blood sugar level is stable, ortholiposis, good recovery of neurological functioning, his mental status has shown a distinct improvement. The patient's speech is more fluent than before. The uvula is now centered. The right side corner of the mouth no longer sags. The pharyngeal reflex is sensitive. His right arm has a muscle force of 4 degrees, his right leg has a muscle force of 5 degrees. He has a steady gait, and can turn much more flexibly.

Case analysis:

Cerebrovascular disease is a type of barrier to the brain's functioning caused by various kinds of vascular encephalopathy. This is a common and frequently-occurring disease. Traditional methods are not effective in the treatment of cerebral infarction. The mortality rate for people suffering from this disease is approximately 10%. After the traditional treatment, 50%-70% of survivors continue to suffer paralysis, aphasia and other serious disabilities. This brings about added burdens to the family members, as well. Stem cell technology has been slowly and meticulously developed, and as a result, the treatment allows a better opportunity for patients to return to society. There are a growing number of patients suffering from cerebrovascular disease who receive this unique treatment and make remarkable progress.

This patient is an elderly male, and his diagnoses were clear upon admission to our medical center. He has cerebral infarction, hypertension, diabetes, and hyperlipidemia. He also has multiple arteriosclerotic risk factors. We treated the patient's neurological malfunctioning which is caused by cerebral infarction, and at the same time we worked on treating the causes of the cerebral infarction.

We focused on the following points:

1. We explained important life style changes the patient needed to make, educated him on the importance of improving his eating habits, and we started from the first-level prevention techniques to fight against the recurrence of cardiovascular and cerebrovascular diseases.

2. Intervene using pathophysiology, control the patient's blood pressure, blood sugar level, blood lipoids and other controllable factors to reverse the progress of arteriosclerosis effectively, and lay a good physiological foundation for the recovery of nerve functioning.

3. According to each patient's individual situation, we conduct a comprehensive and targeted inspection and examination, in order to detect any potential risk factors which will allow early intervention, effectively reducing any risk.

4. Based on the above three points, we use the most advanced stem cell technology to restore the patient's maximum nerve functioning, we combine our unique stem cell technology to promote stem cell growth, as well as specialized recovery training to cause the newly developed stem cells to carry out proper nervous system functioning, that was previously damaged through injury or disease.

Patient Stories:

Name : Won Jonghyuk Sex : Male Nationality : Korean Age : 57Y Diagnosis : 1. Sequel of Storke 2.Hypertension level 2 high risk 3. Diabetes type 2 Date of Admission : October 31th, 2016 Treatment hospital/period: Wu Medical Center/15days Before treat

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Name : Diana Veeramootoo Sex : Female Nationality : Mauritians Age : 43 Diagnoses : 1. Sequela of Stroke, Secondary epilepsy Date of Admission : Sept. 11th, 2016 Treatment hospital/period: Wu Medical Center/14 days Before treatment: In 2012, Diana

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Name : Hong Jong Chul Sex : Male Nationality : Korean Age : 30Y Diagnoses : 1. Stroke 2. Hypertension (1 degree, high risk) Date of Admission: Sept. 20th, 2016 Treatment hospital/period: Wu Medical Center/15days Before treatment: On February 7th, 2

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Name : Bhella Resham Singh Sex : Male Nationality : Indian Age : 67Y Diagnoses : 1. Cerebral hemorrhage sequelae 2. Hypertension grade 2, extremely high-risk 3. Diabetes mellitus type 2 4. Chronic renal insufficiency 5. Hyperlipidemia 6. Hyperhomocys

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Posted at 2016-11-29 by Zhangqi views(92)

Name: Emily Sex: Female Nationality: Italian Age: 26 Years Diagnosis: 1. Sequela of Stroke(Arteriovenous Malformation of Brain) 2. Anemia(mild) 3. Sinus Bradycardia: Occasional Ventricular Extrasystole Date of Admission: Jan.25, 2016 Treatment hospit

Posted at 2016-02-29 by Zhangqi views(147)

Name: Chris Drummond Sex: Male Country: New Zealand Age: 71 years Diagnosis: 1.Sequelae of Cerebral Infarction 2.Mild Anemia 3.Infection of urinary system Date of Admission: November 14th, 2015 Treatment Hospital/period: Wu Medical Center/15 days Be

Posted at 2015-12-10 by Zhangqi views(139)

Name: Hendrik Pieter Kroonenburg Sex: Male Nationality: Germany Age: 35 Years Diagnosis: 1. Stroke 2. Secondary Epilepsy 3. Hypertension 4. Hyperlipemia Date of Admission: July 21, 2015 Treatment hospital/period: Wu Medical Center/22 days Before tre

Posted at 2015-09-04 by Zhangqi views(151)
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